Effective anti-tumor treatment
•Nanograms of peptide reverse established and metastatic tumor growth in TC-1 tumor model
• Other cancer models show synergy with checkpoint blockade inhibition and other anti-tumor treatments
A New Approach for
Short Peptide Cancer Vaccines
• SNAP liposomes contain synthetic MPLA, QS-21 and Cobalt porphyrin phospholipid (CoPoP)
• CoPoP enables liposomes to stably bind short MHC-I epitopes upon admixture.
• Better delivery of epitopes and adjuvants to immune cells in draining lymph nodes
•Induce higher frequency of antigen specific CD8+ T cells with > 10,000X lower peptide dosing
Effective anti-tumor treatment
•Nanograms of peptide reverse established and metastatic tumor growth in TC-1 tumor model
• Other cancer models show synergy with checkpoint blockade inhibition and other anti-tumor treatments
Find the needle in the haystack
• SNAP is ideal for multivalent immunization.
• Short peptide microlibraries with SNAP enables finding functional neoepitopes from candidate lists.
• SNAP vaccines are functional even when 59 irrelevant peptides are mixed with a single functional neoepitope.
Make self-antigens immunogenic
• Self-antigens typically are poorly immunogenic
• SNAP allows unbiased determination of mutated epitopes with enhanced function using a two-step microlibrary screening method
• Success rate of enhanced epitope selection is ~50%. 10 identified so far against 3 target murine epitopes (Trp-2, AH1, WT1).
Path for human testing
• CoPoP made by POP BIO produced under GMP at 2.5M dose scale. Other components are obtainable under GMP.
• CoPoP GLP toxicity report available.
• CoPoP is part of EuCorVac-19, tested in a 280 person ph1/2 trial.
•Testing framework for human epitopes
Peer reviewed publications
POP BIO is actively seeking partners interested in collaborating with the SNAP technology, reach out to us for more information.